Strategic Plan Objective Detail
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Question 4: Objective 5  

Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2008 Question 4: Objective 5 projects (EXCEL)
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Project Title Principal Investigator Institution
Models and mechanisms - 2 Sahin, Mustafa Boston Children's Hospital
Genetic analyses of ARX homeobox gene function in neurodevelopmental disorders Sengupta, Piali Brandeis University
Oxidative stress: Rat study Sajdel-Sulkowska, Ellen Brigham and Women's Hospital
A non-human primate autism model based on maternal infection Patterson, Paul California Institute of Technology
Cellular and molecular alterations in gabaergic inhibitory circuits by mutations in MECP2, a gene implicated in the Rett syndrome of the autism spectrum disorders Huang, Z. Josh Cold Spring Harbor Laboratory
Novel models to define the genetic basis of autism Mills, Alea Cold Spring Harbor Laboratory
Distinct function of the neuroligin 3 postsynaptic adhesion complex Budreck, Elaine Columbia University
Molecular determinants of L-type calcium channel gating Colecraft, Henry Columbia University
Cognitive mechanisms of serially organized behavior Terrace, Herbert Columbia University
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Columbia University
Neurexin-neuroligin trans-syanptic interaction in learning and memory Kandel, Eric Columbia University
Aberrant synaptic function due to TSC mutation in autism Sulzer, David Columbia University Medical Center
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Duke University
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Duke University Medical Center
Perturbed activity dependent plasticity mechanisms in autism Sabatini, Bernardo Harvard Medical School
Connectopathic analysis of autism Sanes, Joshua Harvard University
Investigation of the role of MET kinase in autism Dawson, Ted Johns Hopkins University School of Medicine
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Models and mechanisms - 1 Sur, Mriganka Massachusetts Institute of Technology
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
Regulation of synaptogenesis by cyclin dependent kinase 5 Tsai, Li-Huei Massachusetts Institute of Technology
The role of Shank3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health
Regulation of gene expression in the brain Young, Walter National Institutes of Health
The functional neuroanatomy of memory systems in the human brain Martin, Alex National Institutes of Health