Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2009 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Modeling and pharmacologic treatment of autism spectrum disorders in Drosophila McDonald, Thomas Albert Einstein College of Medicine of Yeshiva University
Neurobiological mechanism of 15q11-13 duplication autism spectrum disorder Anderson, Matthew Beth Israel Deaconess Medical Center
Probing disrupted cortico-thalamic interactions in autism spectrum disorders Fagiolini, Michela Children's Hospital Boston
Analysis of cortical circuits related to ASD gene candidates Zador, Anthony Cold Spring Harbor Laboratory
Novel models to define the genetic basis of autism Mills, Alea Cold Spring Harbor Laboratory
Systematic analysis of neural circuitry in mouse models of autism Osten, Pavel Cold Spring Harbor Laboratory
Molecular determinants of L-type calcium channel gating Colecraft, Henry Columbia University
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Columbia University
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Columbia University
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Duke University
Neurogenetic model of social behavior heterogeneity in autism spectrum disorders Platt, Michael Duke University
Characterization of the transcriptome in an emerging model for social behavior Thomas, James Emory University
Neural mechanisms of social cognition and bonding Young, Larry Emory University
Central vasopressin receptors and affiliation Young, Larry Emory University
Central vasopressin receptors and affiliation Young, Larry Emory University
Vasopressin receptors and social attachment Young, Larry Emory University
Development of genomic resources for prairie voles Young, Larry Emory University
Genomic resources for identifying genes regulating social behavior Young, Larry Emory University
Behavioral, physiological & neuroanatomical consequences of maternal separation Parr, Lisa Emory University
Behavioral and neural processing of faces and expressions in nonhuman primates Parr, Lisa Emory University
Perturbed activity-dependent plasticity mechanisms in autism Sabatini, Bernardo Harvard Medical School
The role of SHANK3 in the etiology of autism spectrum disorder Bangash, M. Johns Hopkins University
Dynamic regulation of Shank3 and ASD Worley, Paul Johns Hopkins University
Investigation of the role of MET kinase in autism Dawson, Ted Johns Hopkins University School of Medicine
The role of CNTNAP2 in embryonic neural stem cell regulation Gaiano, Nicholas Johns Hopkins University School of Medicine