Strategic Plan Objective Detail
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Question 1: Long-term Objective B  

$8,760,010.00
Fiscal Year: 2009

Yellow dot: Objective has some degree of funding, but less than the recommended amount.1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.

Download 2009 Question 1: Long-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Integrated function/structure image analysis in autism Duncan, James Yale University
Social evaluation in infants and toddlers Wynn, Karen Yale University
Perception of social and physical contingencies in infants with ASD Klin, Ami Yale University
Perceptual factors affecting social attention in autism spectrum disorders Macari, Suzanne Yale University
Performance indices of social disability in toddlers with autism Klin, Ami Yale University
ACE Center: Eye-tracking studies of social engagement Klin, Ami Yale University
Ethnicity and the elucidation of autism endophenotypes Constantino, John Washington University in St. Louis
Predicting useful speech in children with autism Yoder, Paul Vanderbilt University
Predicting useful speech in children with autism (supplement) Yoder, Paul Vanderbilt University
Amygdala structure and biochemistry in adolescents with autism Nacewicz, Brendon University of Wisconsin - Madison
ACE Center: Early detection and intervention in infants at risk for autism Dawson, Geraldine University of Washington
Neural mechanisms underlying obsessive compulsiveness in ASD Carrasco, Melisa University of Michigan
Emotion, communication, & EEG: Development & risk Messinger, Daniel University of Miami
Automated measurement of facial expression in autism: Deficits in facial nerve function? Messinger, Daniel University of Miami
Emotional mimicry in children with autism Moody, Eric University of Colorado Denver
Child-initiated communicative interactions and autism intervention Koegel, Robert University of California, Santa Barbara
Magnetic source imaging and sensory behavioral characterization in autism Marco, Elysa University of California, San Francisco
Reward systems in children with autism Scott, Ashley University of California, Los Angeles
Cellular structure of the amygdala in autism Morgan, John University of California, Davis
Analyses of brain structure and connectivity in young children with autism Nordahl, Christine University of California, Davis
Sleep, neuropsychological, mood, behavior, learning, and developmental problems in children with autism Mayes, Susan Penn State College of Medicine
Using a direct observation assessment battery to assess outcome of early intensive behavioral intervention for children with autism MacDonald, Rebecca New England Center for Children
Clinical and behavioral phenotyping of autism and related disorders Swedo, Susan National Institutes of Health (NIH)
Growth and maturation in children with autism Mills, James National Institutes of Health (NIH)
Multimodal studies of executive function deficits in autism spectrum disorders Agam, Yigal Massachusetts General Hospital

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015.

IACC Recommended Budget: $71,100,000 over 5 years
1.4
$5,773,203
18 projects

1.L.B
$8,760,010
34 projects

1.L.B
$15,228,060
52 projects

1.L.B
$9,376,400
42 projects

1.L.B
$12,813,396
39 projects

$51,951,069
1.L.B. Funding: The recommended budget was partially met.

Progress: Over 50 projects were supported in this area. While behavioral and/or biological heterogeneity are well covered by existing projects, gaps still exist in relating these measures to etiology and risk, treatment response, and/or outcomes.

Remaining Gaps, Needs, and Opportunities: There was a discussion of whether this objective should be expanded to be compatible with the Research Domain Criteria (RDoC) now being used by NIMH, which focus on functional domains rather than disorder-specific characteristics.