|Project Title||Principal Investigator||Institution|
|Integrated function/structure image analysis in autism||Duncan, James||Yale University|
|Social evaluation in infants and toddlers||Wynn, Karen||Yale University|
|Perception of social and physical contingencies in infants with ASD||Klin, Ami||Yale University|
|Performance indices of social disability in toddlers with autism||Klin, Ami||Yale University|
|ACE Center: Eye-tracking studies of social engagement||Klin, Ami||Yale University|
|Perceptual factors affecting social attention in autism spectrum disorders||Macari, Suzanne||Yale University|
|Ethnicity and the elucidation of autism endophenotypes||Constantino, John||Washington University in St. Louis|
|Predicting useful speech in children with autism||Yoder, Paul||Vanderbilt University|
|Predicting useful speech in children with autism (supplement)||Yoder, Paul||Vanderbilt University|
|Amygdala structure and biochemistry in adolescents with autism||Nacewicz, Brendon||University of Wisconsin - Madison|
|ACE Center: Early detection and intervention in infants at risk for autism||Dawson, Geraldine||University of Washington|
|Neural mechanisms underlying obsessive compulsiveness in ASD||Carrasco, Melisa||University of Michigan|
|Emotion, communication, & EEG: Development & risk||Messinger, Daniel||University of Miami|
|Automated measurement of facial expression in autism: Deficits in facial nerve function?||Messinger, Daniel||University of Miami|
|Emotional mimicry in children with autism||Moody, Eric||University of Colorado Denver|
|Child-initiated communicative interactions and autism intervention||Koegel, Robert||University of California, Santa Barbara|
|Magnetic source imaging and sensory behavioral characterization in autism||Marco, Elysa||University of California, San Francisco|
|Reward systems in children with autism||Scott, Ashley||University of California, Los Angeles|
|Cellular structure of the amygdala in autism||Morgan, John||University of California, Davis|
|Analyses of brain structure and connectivity in young children with autism||Nordahl, Christine||University of California, Davis|
|Sleep, neuropsychological, mood, behavior, learning, and developmental problems in children with autism||Mayes, Susan||Penn State College of Medicine|
|Using a direct observation assessment battery to assess outcome of early intensive behavioral intervention for children with autism||MacDonald, Rebecca||New England Center for Children|
|Clinical and behavioral phenotyping of autism and related disorders||Swedo, Susan||National Institutes of Health (NIH)|
|Growth and maturation in children with autism||Mills, James||National Institutes of Health (NIH)|
|A prospective multi-system evaluation of infants at risk for autism||Bauman, Margaret||Massachusetts General Hospital|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015.
IACC Recommended Budget: $71,100,000 over 5 years
|1.L.B. Funding: The recommended budget was partially met.
Progress: Over 50 projects were supported in this area. While behavioral and/or biological heterogeneity are well covered by existing projects, gaps still exist in relating these measures to etiology and risk, treatment response, and/or outcomes.
Remaining Gaps, Needs, and Opportunities: There was a discussion of whether this objective should be expanded to be compatible with the Research Domain Criteria (RDoC) now being used by NIMH, which focus on functional domains rather than disorder-specific characteristics.