Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Baylor College of Medicine
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Baylor College of Medicine
Presynaptic fragile X proteins Akins, Michael Brown University
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Children's Hospital Boston
Probing disrupted cortico-thalamic interactions in autism spectrum disorders Fagiolini, Michela; Chen, Chinfei Children's Hospital Boston
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Children's Memorial Hospital, Chicago
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Cold Spring Harbor Laboratory
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Cold Spring Harbor Laboratory
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Cold Spring Harbor Laboratory
Aberrant synaptic form and function due to TSC-mTOR-related mutation in autism spectrum disorders Sulzer, David Columbia University
Aberrant synaptic function caused by TSC mutation in autism Sulzer, David Columbia University
New approaches to local translation: SpaceSTAMP of proteins synthesized in axons Segal, Rosalind Dana-Farber Cancer Institute
Quantitative proteomic approach towards understanding and treating autism Jin, Peng Emory University
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Emory University
Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome Corbin, Joshua George Washington University
Activity-dependent phosphorylation of MeCP2 Ebert, Daniel Harvard Medical School
Neuronal activity-dependent regulation of MeCP2 Greenberg, Michael Harvard Medical School
Neuronal activity-dependent regulation of MeCP2 (supplement) Greenberg, Michael Harvard Medical School
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao J. David Gladstone Institutes
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Johns Hopkins University
Development of novel diagnostics for fragile X syndrome Hosono, Seiyu JS Genetics, Inc.
MicroRNAs in synaptic plasticity and behaviors relevant to autism Kelleher, Raymond Massachusetts General Hospital
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Massachusetts Institute of Technology
Gene silencing in fragile X syndrome Usdin, Karen National Institutes of Health
Translation regulation in hippocampal LTP and LTD Klann, Eric New York University