Strategic Plan Objective Detail
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Question 2: Short-term Objective E  

Fiscal Year: 2009

New! Green dot: Objective has greater than or equal to the recommended funding.2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism including seizures/epilepsy, sleep disorders and familial autoimmune disorders by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2009 Question 2: Short-term Objective E projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Treatment of sleep problems in children with autism spectrum disorder with melatonin: A double-blind, placebo-controlled study Hopkins, Bobbi Baylor College of Medicine
Understanding the cognitive impact of early life epilepsy Jensen, Frances Children's Hospital Boston
Selective disruption of hippocampal dentate granule cells in autism: Impact of PTEN deletion Danzer, Steve Cincinnati Children's Hospital Medical Center
Treatment of medical conditions among individuals with autism spectrum disorders Swedo, Susan National Institutes of Health (NIH)
Neural dissection of hyperactivity/inattention in autism Castellanos, Francisco Xavier New York University School of Medicine
Molecular components of A-type K+ channels Rudy, Bernardo New York University School of Medicine
Gastrointestinal functions in autism Duffey, Michael University at Buffalo, The State University of New York
Etiology of sleep disorders in ASD: Role of inflammatory cytokines Mong, Jessica University of Maryland, Baltimore
Neurological diseases due to inborn errors of metabolism Pascual, Juan University of Texas Southwestern Medical Center
ACE Center: Structural and chemical brain imaging of autism Dager, Stephen University of Washington
Relation of sleep epileptiform discharges to insomnia and daytime behavior Barnes, Gregory Vanderbilt University

Objective Multiyear Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012.

IACC Recommended Budget: $9,000,000 over 5 years

11 projects

14 projects

23 projects

22 projects

2.S.E. Funding: The recommended budget for this objective was met.

Progress: More than twenty projects were funded that were specific to this objective. Scientific advances in this area include mechanistic and mutation linkages of epilepsy and ASD-like behaviors, as well as circadian rhythm disruptions downstream of ASD-associated mutations.

Remaining Gaps, Needs and Opportunities: While studies on co-occurring conditions have been initiated, a greater depth of understanding is needed. Further efforts are needed, especially on wandering, metabolic and immune conditions related to ASD, as well as a systems-biology approach to understand how these co-occurring conditions are related to ASD. In order to more accurately assess progress, wandering/elopement should be considered separately from seizures/epilepsy/sleep. Familial autoimmune disorders could be moved to 2.S.A to be grouped with other immune-related issues.