Strategic Plan Objective Detail
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Question 2: Short-term Objective G  

Fiscal Year: 2009

New! Green dot: Objective has greater than or equal to the recommended funding.2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Download 2009 Question 2: Short-term Objective G projects (EXCEL)
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Project Title Principal Investigator Institution
Cellular and genetic correlates of increased head size in autism spectrum disorder Vaccarino, Flora Yale University
Longitudinal neurogenetics of atypical social brain development in autism Pelphrey, Kevin Yale University
Regulation of MET expression in autism disorder and forebrain ontogeny Bergman, Mica Vanderbilt University
Neuroligin function in vivo: Implications for autism and mental retardation Powell, Craig University of Texas Southwestern Medical Center
Neural circuitry of social cognition in the broad autism phenotype Piven, Joseph University of North Carolina at Chapel Hill
fMRI evidence of genetic influence on rigidity in ASD Lee, Jillian University of Michigan
Neural correlates of serotonin transporter gene polymorphisms and social impairment in ASD Monk, Christopher University of Michigan
Autism: Neuropeptide hormones and potential pathway genes Jacob, Suma University of Illinois at Chicago
Self-injurious behavior: An animal model of an autism endophenotype Devine, Darragh University of Florida
Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models Dulawa, Stephanie University of Chicago
Autism-specific mutation in DACT1: Impact on brain development in a mouse model Cheyette, Benjamin University of California, San Francisco
Patient iPS cells with copy number variations to model neuropsychiatric disorders Ellis, James The Hospital for Sick Children
Using induced pluripotent stem cells to identify cellular phenotypes of autism Dolmetsch, Ricardo Stanford University
A systematic test of the relation of ASD heterogeneity to synaptic function Sudhof, Thomas Stanford University
Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells Hallmayer, Joachim Stanford University
A neuroimaging study of twin pairs with autism Hardan, Antonio Stanford University
The brain genomics superstruct project Buckner, Randy L. President & Fellows of Harvard College
Rapid characterization of balanced genomic rearrangements contributing to autism Talkowski, Michael Massachusetts General Hospital
Multimodal neuroimaging of white matter in autism Herbert, Martha Massachusetts General Hospital
Language processing in children with 22q11 deletion syndrome and autism Ousley, Opal Emory University
Autism: The neural substrates of language in siblings Lindgren, Kristen Boston University Medical Campus