|Project Title||Principal Investigator||Institution|
|Vulnerability phenotypes and susceptibility to environmental toxicants: From organism to mechanism||Noble, Mark||University of Rochester|
|Gene expression and immune cell function in mothers of children with autism||Sharp, Frank; Ashwood, Paul; Van de Water, Judy||University of California, Davis|
|Immunobiology in autism||Van de Water, Judy||University of California, Davis|
|Etiology of autism risk involving MET gene and the environment||Van de Water, Judy||University of California, Davis|
|Evaluation of the immune and physiologic response in children with autism following immune challenge||Van de Water, Judy||University of California, Davis|
|Autism spectrum disorder and autoimmune disease of mothers||Diamond, Betty||The Feinstein Institute for Medical Research|
|Does thimerosal elicit a hormetic response?||Deth, Richard||Northeastern University|
|Psychosis and autoimmune diseases in Denmark||Eaton, William||Johns Hopkins University|
|Research project about a potential infectious origin of autism||Montagnier, Luc||Institut de Recherche Luc Montagnier|
|Genetic and immunological risk factors for autism||Gregersen, Peter||Feinstein Institute For Medical Research|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support at least two studies to determine if there are subpopulations that are more susceptible to environmental exposures (e.g., immune challenges related to infections, vaccinations, or underlying autoimmune problems) by 2012.
IACC Recommended Budget: $8,000,000 over 2 years
|3.S.E. Funding: The recommended budget was partially met.
Progress: Several projects were funded in this area, going beyond the minimum recommended by the committee, but the projects have been smaller than what was expected. However, even with smaller studies, a large amount of data has been collected relating to immunological conditions in children and mothers.
Remaining Gaps, Needs, and Opportunities: More work is needed to analyze and interpret available data.