Strategic Plan Objective Detail
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Question 4: Objective 5  

Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2008 Question 4: Objective 5 projects (EXCEL)
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Project Title Principal Investigator Institution
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Whitehead Institute for Biomedical Research
Regulation of MET expression in autism disorder and forebrain ontogeny Bergman, Mica Vanderbilt University
Neurodevelopmental mechanisms of social behavior Levitt, Pat Vanderbilt University
Steroid receptors and brain sex differences Auger, Anthony University of Wisconsin - Madison
Dysregulation of p13/AKT in mouse models for social interaction deficits and for ASD with macrocephaly Parada, Luis University of Texas Southwestern Medical Center
A mouse knock-in model for Engrailed 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
Analysis of FGF17 roles and regulation in mammalian forebrain development Hoch, Renee University of California, San Francisco
Role of Wnt signaling through Dishevelled, Dact and p120catenin in forebrain development, synaptic physiology, and mouse behavior: Exploration of a pathway with many components linked to autism spectrum disorders Reichardt, Louis University of California, San Francisco
Neocortical regionalization: Analysis of genetic and epigenetic influences Huffman, Kelly University of California, Riverside
Analysis of 15q11-13 GABA-A receptor defects in autism Hogart, Amber University of California, Davis
Exploring the role of synaptic proteins in mouse models of autism Heintz, Nathaniel The Rockefeller University
A better understanding of the therapeutic actions of specific neuroleptics in autism Greengard, Paul The Rockefeller University
Function and dysfunction of neuroligins Sudhof, Thomas Stanford University
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Stanford University
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University
Testing the effects of cortical disconnection in non-human primates Krauzlis, Richard Salk Institute for Biological Studies
Generation of genetic models of autism in mice Fishell, Gordon New York University School of Medicine
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health
Regulation of gene expression in the brain Young, Walter National Institutes of Health
The functional neuroanatomy of memory systems in the human brain Martin, Alex National Institutes of Health
The role of Shank3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Models and mechanisms - 1 Sur, Mriganka Massachusetts Institute of Technology
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
Regulation of synaptogenesis by cyclin dependent kinase 5 Tsai, Li-Huei Massachusetts Institute of Technology