|Project Title||Principal Investigator||Institution|
|Environmentally induced oxidative stress and altered local brain thyroid horomone metabolism: relevance to autism?||Sajdel-Sulkowski, Elizabeth||Harvard Medical School; Brigham and Women's Hospital|
|EFRI- BSBA: Novel microsystems for manipulation and analysis of immune cells||Revzin, Alexander||University of California, Davis|
|Early biologic markers for autism||Croen, Lisa||Kaiser Permanente Division of Research|
|Does mercury and neurotension induce mitochondrial DNA release from human mast cells and contribute to auto-immunity in ASD?||Theohardies, Theoharis||Tufts University|
|Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance||Rall, Glenn||The Fox Chase Cancer Center|
|CNS toxicity of ambient air pollution: Postnatal exposure to ultrafine particles||Cory-Slechta, Deborah||University of Rochester|
|A role for immune molecules in cortical connectivity: Potential implications for autism||Elmer, Bradford||University of California, Davis|
|A primate model of gut, immune, and CNS response to childhood vaccines||Sackett, Gene||University of Washington|
|A non-human primate autism model based on maternal infection||Patterson, Paul||California Institute of Technology|
|A non-human primate autism model based on maternal immune activation||Patterson, Paul||University of California, Davis|
|An ex-vivo placental perfusion system to study materno-fetal biology||Bonnin, Alexandre||University of Southern California|
|A mitochondrial etiology of autism||Wallace, Douglas||Children's Hospital of Philadelphia|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010 (Fever studies to be started by 2012).
IACC Recommended Budget: $9,800,000 over 4 years
|2.S.A. Funding: The recommended budget for this objective was met.
Progress: Many projects were funded in this area (approximately 20-30 per year), but the field is still developing, and emphasis on this objective should continue in the future. Scientific advances have been made in linking maternal innate immune function and immune-system challenge to aspects of ASD. Methodological advances in the field include the development of animal models for study of the role of the immune system in ASD and PET ligands for imaging microglial activation.
Remaining Gaps, Needs and Opportunities: There is a need for a well-designed, multi-site clinical study of clinical effects of fever and to develop standard measures of fever and behavioral/cognitive outcomes. Questions about fever could be integrated into funded epidemiological studies. There is also interest in further work on metabolic and mitochondrial issues, but in order for this work to be done, there is a need for validation and standardization of measures for assessment of oxidative stress and mitochondrial function. More guidance is needed on the key questions for this field to answer â a workshop to define these methodologies may be helpful. One of the key questions is to determine whether it is the body temperature associated with fever or some consequence of immune activation and production of the febrile state that leads to amelioration of cognitive function.