Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Neuronal activity-dependent regulation of MeCP2 Greenberg, Michael Harvard Medical School
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Cold Spring Harbor Laboratory
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis University of Texas Southwestern Medical Center
Molecular basis of autism associated with human adenylosuccinate lyase gene defects Colman, Roberta University of Delaware
Modulation of fxr1 splicing as a treatment strategy for autism in fragile X syndrome Lin, Michael Stanford University
MicroRNAs in synaptic plasticity and behaviors relevant to autism Kelleher, Raymond Massachusetts General Hospital
MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism Pozzo-Miller, Lucas University of Alabama at Birmingham
L-type calcium channel regulation of neuronal differentiation Panagiotakos, Georgia Stanford University
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Baylor College of Medicine
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Massachusetts Institute of Technology
Genotype-phenotype relationships in fragile X families Hagerman, Randi University of California, Davis
Genetic and developmental analyses of fragile X syndrome Broadie, Kendal Vanderbilt University
Gene silencing in fragile X syndrome Usdin, Karen National Institutes of Health
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Emory University
Functional circuit disorders of sensory cortex in ASD and RTT Carlson, Gregory University of Pennsylvania
Establishing zebrafish as a model for RAI1 gene dosage Elsea, Sarah; Lister, James Virginia Commonwealth University
Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome Corbin, Joshua George Washington University
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Baylor College of Medicine
Development of novel diagnostics for fragile X syndrome Hosono, Seiyu JS Genetics, Inc.
Developmental versus acute mechanisms mediating altered excitatory synaptic function in the fragile X syndrome mouse model Huber, Kimberly University of Texas Southwestern Medical Center
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome Gibson, Jay University of Texas Southwestern Medical Center
Coordinated control of synapse development by autism-linked genes Huber, Kimberly University of Texas Southwestern Medical Center
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Cold Spring Harbor Laboratory
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Cold Spring Harbor Laboratory
BDNF and the restoration of spine plasticity with autism spectrum disorders Gall, Christine University of California, Irvine