|Project Title||Principal Investigator||Institution|
|Performance indices of social disability in toddlers with autism||Klin, Ami||Yale University|
|Plasticity in autism spectrum disorders: Magnetic stimulation studies||Oberman, Lindsay||Beth Israel Deaconess Medical Center|
|Predicting useful speech in children with autism||Yoder, Paul||Vanderbilt University|
|Predicting useful speech in children with autism (supplement)||Yoder, Paul||Vanderbilt University|
|Reward systems in children with autism||Scott, Ashley||University of California, Los Angeles|
|Sleep, neuropsychological, mood, behavior, learning, and developmental problems in children with autism||Mayes, Susan||Penn State College of Medicine|
|Social evaluation in infants and toddlers||Wynn, Karen||Yale University|
|Temperament, emotional expression, and emotional self-regulation in relation to later ASD diagnosis||Wozniak, Robert||Bryn Mawr College|
|Using a direct observation assessment battery to assess outcome of early intensive behavioral intervention for children with autism||MacDonald, Rebecca||New England Center for Children|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015.
IACC Recommended Budget: $71,100,000 over 5 years
|1.L.B. Funding: The recommended budget was partially met.
Progress: Over 50 projects were supported in this area. While behavioral and/or biological heterogeneity are well covered by existing projects, gaps still exist in relating these measures to etiology and risk, treatment response, and/or outcomes.
Remaining Gaps, Needs, and Opportunities: There was a discussion of whether this objective should be expanded to be compatible with the Research Domain Criteria (RDoC) now being used by NIMH, which focus on functional domains rather than disorder-specific characteristics.