Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

Fiscal Year: 2009

New! Yellow dot: Objective has some degree of funding, but less than the recommended amount.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2009 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Identification of UBE3A substrates using proteomic profiling in Drosophila Reiter, Lawrence University of Tennessee Health Science Center
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Massachusetts Institute of Technology
Molecular basis of autism associated with human adenylosuccinate lyase gene defects Colman, Roberta University of Delaware
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis University of Texas Southwestern Medical Center
Mouse models of the neuropathology of tuberous sclerosis complex Gambello, Michael University of Texas Health Science Center at Houston
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Cold Spring Harbor Laboratory
Neuroligin regulation of central GABAergic synapses Fu, Zhanyan Duke University
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Johns Hopkins University
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Stanford University
Proteomics in Drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence University of Tennessee Health Science Center
Proteomics in Drosophila to identify autism candidate substrates of UBE3A (supplement) Reiter, Lawrence University of Tennessee Health Science Center
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony University of North Carolina at Chapel Hill
Role of excitation and inhibition in Rett syndrome Chao, Hsiao-Tuan Baylor College of Medicine
Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses Engelman, Holly Albert Einstein College of Medicine of Yeshiva University
Sex differences in early brain development: Brain development in Turner syndrome Santelli, Rebecca Knickmeyer University of North Carolina at Chapel Hill
Synaptic analysis of neuroligin 1 function Fuccillo, Marc Stanford University
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism Morris, Jill Children's Memorial Hospital, Chicago
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao J. David Gladstone Institutes
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan University of California, San Diego
Translation regulation in hippocampal LTP and LTD Klann, Eric New York University
TrkB agonist(s), a potential therapy for autism spectrum disorders Sun, Yi University of California, Los Angeles
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Children's Hospital Boston
White matter connections of the face processing network in children and adults Yoon, Jennifer Stanford University