|Project Title||Principal Investigator||Institution|
|Genes that deregulate mTOR signaling as candidates for autism spectrum disorders||Ramesh, Vijaya||Massachusetts General Hospital|
|Genetic analysis of 15q11-q13 in autism||Sutcliffe, James||Vanderbilt University|
|Genetic basis of autism||Wigler, Michael||Cold Spring Harbor Laboratory|
|Genetic contributions to endophenotypes of autism||Wijsman, Ellen||University of Washington|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Genetic studies in autism on chromosome 7||Pericak-Vance, Margaret||Duke University|
|Genetic studies of autism susceptibility||Brzustowicz, Linda||Rutgers University|
|Genetic study of restricted repetitive behavior in autism spectrum disorders||Kim, Soo-Jeong||University of Florida|
|Genomic imbalances in autism - AS||Kumar, Ravinesh||University of Chicago|
|Genomic imbalances in autism - NIH||Christian, Susan||University of Chicago|
|Genomic resources for identifying genes regulating social behavior||Young, Larry||Emory University|
|Genotype-phenotype relationships in fragile X families||Hagerman, Randi||University of California, Davis|
|Hindbrain dysgenesis in Rett syndrome and other autism spectrum disorders||Swanberg, Susan||University of California, Davis|
|Identification and functional assessment of autism susceptibility genes - 1||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|Identification and functional assessment of autism susceptibility genes - 3||Vieland, Veronica||The Research Institute at Nationwide Children's Hospital|
|Identification and functional assessment of autism susceptibity genes - 2||Millonig, James||University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School|
|Identification of autism candidate genes on the X-chromosome from copy number variants identified by 500K SNP-CHIP analysis||Vincent, John||Centre For Addiction And Mental Health|
|Identifying and understanding the action of autism susceptibility genes||Monaco, Anthony||University of Oxford|
|Identifying autism susceptibility genes by high-throughput chip resequencing||Zwick, Michael||Emory University|
|Isolation of autism susceptibility genes||Stefansson, Kari||Decode Genetics, Inc.|
|Molecular analysis core||Pericak-Vance, Margaret||Duke University|
|Mutation analysis of candidate genes derived from an autism protein interaction network in SSC autism samples||Zoghbi, Huda||Baylor College of Medicine|
|Neural circuitry of social cognition in the broad autism phenotype||Piven, Joseph||University of North Carolina at Chapel Hill|
|Neurobiology of sociability in a mouse model system relevant to autism||Brodkin, Edward||University of Pennsylvania|
|Neurogenetics of candidate systems in autism||Haines, Jonathan||Duke University|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.