|Project Title||Principal Investigator||Institution|
|Genes disrupted by balanced genomic rearrangements in autism spectrum disorders||Gusella, James||Massachusetts General Hospital|
|Genetic basis of autism||Wigler, Michael||Cold Spring Harbor Laboratory|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Genetic investigation of cognitive development in autistic spectrum disorders||Morrow, Eric||Brown University|
|Genetics of autism intermediate phenotypes||Coon, Hilary||University of Utah|
|Genetic studies in autism on chromosome 7 (supplement)||Pericak-Vance, Margaret||Duke University|
|Genome-wide analyses of DNA methylation in autism||Chess, Andrew||Massachusetts General Hospital|
|Genomic hotspots of autism||Eichler, Evan||University of Washington|
|Genomic imbalances in autism||Kumar, Ravinesh||University of Chicago|
|Identification and functional assessment of autism susceptibility genes||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|Identification and functional assessment of autism susceptibility genes||Vieland, Veronica||The Research Institute at Nationwide Children's Hospital|
|Identification and functional assessment of autism susceptibility genes||Millonig, James||University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School|
|Identification of aberrantly methylated genes in autism: The role of advanced paternal age||Gingrich, Jay||Research Foundation for Mental Hygiene, Inc.|
|Identifying and understanding the action of autism susceptibility genes||Monaco, Anthony||University of Oxford|
|Identifying autism susceptibility genes by high-throughput chip resequencing||Zwick, Michael||Emory University|
|Illumina, Inc.||No PI listed||Illumina, Inc.|
|Integrative genetic analysis of autistic brains||Arking, Dan||Johns Hopkins University School of Medicine|
|Investigation of genes involved in synaptic plasticity in Iranian families with ASD||Santangelo, Susan||Massachusetts General Hospital|
|Isolation of autism susceptibility genes||Stefansson, Kari||deCODE Genetics, Inc.|
|Molecular Analysis Core (supplement)||Pericak-Vance, Margaret||Duke University|
|Molecular and genetic epidemiology of autism||Pericak-Vance, Margaret||University of Miami Miller School of Medicine|
|Neurogenetics of candidate systems in autism (supplement)||Haines, Jonathan||Duke University|
|Pathway-based genetic studies of autism spectrum disorder||Bucan, Maja||University of Pennsylvania|
|Pilot project to assess web-based family recruitment for autism genetics studies||Nelson, Stan; Constantino, John; Law, Paul||University of California, Los Angeles; Washington University in St. Louis; Kennedy Krieger Institute|
|Potential role of non-coding RNAs in autism||Talebizadeh, Zohreh||Children's Mercy Hospitals And Clinics|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.