|Project Title||Principal Investigator||Institution|
|Signatures of gene expression in autism spectrum disorders||Kunkel, Louis||Children's Hospital Boston|
|ACE Center: Linguistic and social responses to speech in infants at risk for autism||Kuhl, Patricia||University of Washington|
|Model diagnostic lab for infants at risk for autism||Klin, Ami||Yale University|
|The ontogeny of social visual engagement in infants at risk for autism||Klin, Ami||Yale University|
|ACE Center: Assessment Core||Klin, Ami||Yale University|
|Identification of lipid biomarkers for autism||Kang, Jing||Massachusetts General Hospital|
|Metabolic biomarkers of autism: Predictive potential and genetic susceptibility||James, Sandra||Arkansas Children's Hospital Research Institute|
|Early identification of autism: A prospective study||Iverson, Jana||University of Pittsburgh|
|Misregulation of BDNF in autism spectrum disorders||Hempstead, Barbara||Weill Cornell Medical College|
|ACE Center: Data Management and Analysis Core||Grigorenko, Elena||Yale University|
|ACE Center: Administrative Core||Eichenbaum, Howard||University of California, San Diego|
|Development of neural pathways in infants at risk for autism spectrum disorders||Dobkins, Karen||University of California, San Diego|
|A longitudinal 3-D MRSI study of infants at high risk for autism||Dager, Stephen||University of Washington|
|ACE Center: MRI studies of early brain development in autism||Courchesne, Eric||University of California, San Diego|
|Pupil size and circadian salivary variations in autism spectrum disorder||Colombo, John||University of Kansas|
|ACE Center: Gaze perception abnormalities in infants with ASD||Chawarska, Katarzyna||Yale University|
|Prospective study of infants at high risk for autism||Chawarska, Katarzyna||Yale University|
|Biomarkers for autism and for gastrointestinal and sleep problems in autism||Anderson, George||Yale University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014.
IACC Recommended Budget: $33,300,000 over 5 years
|1.L.A. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: More than 40 projects have been supported in this area, but most projects are still in the discovery phase. Identifying reliable early biomarkers has been challenging, but some progress has been made. More work is needed to achieve the full intent of the objective.
Remaining Gaps, Needs, and Opportunities: Remaining research needs include continued discovery of biomarkers, linking biomarkers to treatment response, validation of biomarkers discovered in high risk populations for applicability in the general population, and evaluation of whether these biomarkers translate to improvement in screening and diagnosis real-world settings. There is also a need for biomarkers that are cost-effective.