Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2009 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Animal models of autism: Pathogenesis and treatment Powell, Craig University of Texas Southwestern Medical Center
Novel genetic animal models of autism Powell, Craig University of Texas Southwestern Medical Center
Neurogenetic model of social behavior heterogeneity in autism spectrum disorders Platt, Michael Duke University
A non-human primate autism model based on maternal immune activation Patterson, Paul University of California, Davis
Behavioral and neural processing of faces and expressions in nonhuman primates Parr, Lisa Emory University
Behavioral, physiological & neuroanatomical consequences of maternal separation Parr, Lisa Emory University
Dysregulation of PI3K/AKT in social interaction deficits and autism spectrum disorders with macrocephaly Parada, Luis University of Texas Southwestern Medical Center
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University
Systematic analysis of neural circuitry in mouse models of autism Osten, Pavel Cold Spring Harbor Laboratory
Characterization of a novel mouse model of restricted repetitive behaviors Moy, Sheryl University of North Carolina at Chapel Hill
Novel models to define the genetic basis of autism Mills, Alea Cold Spring Harbor Laboratory
A mouse knock-in model for ENGRAILED 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
Modeling and pharmacologic treatment of autism spectrum disorders in Drosophila McDonald, Thomas Albert Einstein College of Medicine of Yeshiva University
Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders Malanga, C.J. University of North Carolina School of Medicine
Using Drosophila to model the synaptic function of the autism-linked NHE9 Littleton, J. Troy Massachusetts Institute of Technology
Serotonin, corpus callosum, and autism Lin, Rick University of Mississippi Medical Center
The genetics of restricted, repetitive behavior: An inbred mouse model Lewis, Mark University of Florida
Behavioral and physiological consequences of disrupted Met signaling Levitt, Pat University of Southern California
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Columbia University
A comparative developmental connectivity study of face processing Joseph, Jane University of Kentucky
Neurogenomics in a model for procedural learning Hilliard, Austin University of California, Los Angeles
A proposal to define cells and circuits impacted in autism spectrum disorders Heintz, Nathaniel The Rockefeller University
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Columbia University
The role of CNTNAP2 in embryonic neural stem cell regulation Gaiano, Nicholas Johns Hopkins University School of Medicine
Functional genomic dissection of language-related disorders Fisher, Simon University of Oxford