Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2010 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Preclinical testing of novel oxytocin receptor activators in models of autism phenotypes Moy, Sheryl University of North Carolina at Chapel Hill
Serotonin, corpus callosum, and autism Lin, Rick University of Mississippi Medical Center
A mouse knock-in model for ENGRAILED 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey
The genetic control of social behavior in the mouse Blanchard, Robert University of Hawai'i at Manoa
The genetics of restricted, repetitive behavior: An inbred mouse model Lewis, Mark University of Florida
Insight into MeCP2 function raises therapeutic possibilities for Rett syndrome Lomvardas, Stavros University of California, San Francisco
Dissecting the neural control of social attachment Shah, Nirao University of California, San Francisco
Role of a novel Wnt pathway in autism spectrum disorders Reichardt, Louis University of California, San Francisco
High content screens of neuronal development for autism research Halpain, Shelley University of California, San Diego
Cntnap2 in a behavioral model of autism White, Stephanie University of California, Los Angeles
Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy Yang, Xiangdong University of California, Los Angeles
Neurogenomics in a model for procedural learning Hilliard, Austin University of California, Los Angeles
A novel cell-based assay for autism research and drug discovery Restifo, Linda University of Arizona
Small-molecule compounds for treating autism spectrum disorders Philpot, Ben The University of North Carolina at Chapel Hill
Autism iPSCs for studying function and dysfunction in human neural development Loring, Jeanne The Scripps Research Institute
Serotonin, autism, and investigating cell types for CNS disorders Dougherty, Joseph The Rockefeller University
Patient iPS cells with copy number variations to model neuropsychiatric disorders Ellis, James The Hospital for Sick Children
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Stanford University
Using induced pluripotent stem cells to identify cellular phenotypes of autism Dolmetsch, Ricardo Stanford University
Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells Hallmayer, Joachim; Dolmetsch, Ricardo Stanford University
Synaptic deficits of iPS cell-derived neurons from patients with autism Mao, Rong Stanford University
Function and dysfunction of neuroligins Sudhof, Thomas Stanford University
Identification of autism genes that regulate synaptic Nrx/Nlg signaling complexes Garner, Craig Stanford University
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University
Methods for production of ICSI and SCNT derived macaque stem cells Schatten, Gerald Southwest Foundation For Biomedical Research