Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2009 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Massachusetts Institute of Technology
Regulation of synaptogenesis by cyclin-dependent kinase 5 Tsai, Li-Huei Massachusetts Institute of Technology
Using Drosophila to model the synaptic function of the autism-linked NHE9 Littleton, J. Troy Massachusetts Institute of Technology
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Massachusetts Institute of Technology
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Mount Sinai School of Medicine
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
Studies on protein synthesis and long-term adaptive responses in the CNS Smith, Carolyn National Institutes of Health (NIH)
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health (NIH)
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie New York University
The integration of interneurons into cortical microcircuits Fishell, Gordon New York University School of Medicine
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University
Function and dysfunction of neuroligins Sudhof, Thomas Stanford University
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Stanford University
Serotonin, autism, and investigating cell types for CNS disorders Dougherty, Joseph The Rockefeller University
A proposal to define cells and circuits impacted in autism spectrum disorders Heintz, Nathaniel The Rockefeller University
A novel cell-based assay for autism research and drug discovery Restifo, Linda University of Arizona
Primate models of autism Amaral, David University of California, Davis
A non-human primate autism model based on maternal immune activation Patterson, Paul University of California, Davis
CNTNAP2 in a behavioral model of autism White, Stephanie University of California, Los Angeles
Neurogenomics in a model for procedural learning Hilliard, Austin University of California, Los Angeles
Functional analysis of neurexin IV in Drosophila Zipursky, Larry University of California, Los Angeles
Dissecting the neural control of social attachment Shah, Nirao University of California, San Francisco
Role of Wnt signaling in forebrain development, synaptic physiology, and mouse behavior Reichardt, Louis University of California, San Francisco