Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

$20,162,709.18
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2009 Question 4: Short-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Massachusetts Institute of Technology
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
Regulation of synaptogenesis by cyclin-dependent kinase 5 Tsai, Li-Huei Massachusetts Institute of Technology
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Massachusetts Institute of Technology
Using Drosophila to model the synaptic function of the autism-linked NHE9 Littleton, J. Troy Massachusetts Institute of Technology
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Mount Sinai School of Medicine
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health (NIH)
Studies on protein synthesis and long-term adaptive responses in the CNS Smith, Carolyn National Institutes of Health (NIH)
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie New York University
The integration of interneurons into cortical microcircuits Fishell, Gordon New York University School of Medicine
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Stanford University
Function and dysfunction of neuroligins Sudhof, Thomas Stanford University
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University
Serotonin, autism, and investigating cell types for CNS disorders Dougherty, Joseph The Rockefeller University
A proposal to define cells and circuits impacted in autism spectrum disorders Heintz, Nathaniel The Rockefeller University
A novel cell-based assay for autism research and drug discovery Restifo, Linda University of Arizona
Primate models of autism Amaral, David University of California, Davis
A non-human primate autism model based on maternal immune activation Patterson, Paul University of California, Davis
CNTNAP2 in a behavioral model of autism White, Stephanie University of California, Los Angeles
Functional analysis of neurexin IV in Drosophila Zipursky, Larry University of California, Los Angeles
Neurogenomics in a model for procedural learning Hilliard, Austin University of California, Los Angeles
Dissecting the neural control of social attachment Shah, Nirao University of California, San Francisco
Role of a novel Wnt pathway in autism spectrum disorders Reichardt, Louis University of California, San Francisco

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.

IACC Recommended Budget: $75,000,000 over 5 years
4.5
$15,879,827
42 projects

4.S.B
$20,162,709
70 projects

4.S.B
$23,229,501
92 projects

4.S.B
$21,606,118
89 projects

4.S.B
$21,232,514
94 projects

$102,110,669
4.S.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: More than 90 projects were supported to develop animal models.

Remaining Gaps, Needs, and Opportunities: Planning Group members discussed whether the amount of investment in this area is appropriate when compared to investments in clinical trials and other later stage studies. Invited experts suggested that the current stage of scientific research in ASD requires pre-clinical research to identify targets from animal and cellular models. Similar to cancer treatment development pathways, which spanned 20-30 years, research in ASD must invest in model systems to understand the fundamental biology from which translation to the clinic can be built. The translational validity of research in non-human animals cannot be determined until human trials are conducted, thus the need for rapid progress to clinical studies in humans is important.