Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

Fiscal Year: 2009

New! Yellow dot: Objective has some degree of funding, but less than the recommended amount.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2009 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony University of North Carolina at Chapel Hill
Autism iPSCs for studying function and dysfunction in human neural development Loring, Jeanne Scripps Research Institute
An investigation of neuropsychological endophenotypes in autism and fragile X Martin, Gary Everett University of North Carolina at Chapel Hill
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism Morris, Jill Children's Memorial Hospital, Chicago
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis University of Texas Southwestern Medical Center
Clinical correlations of contiguous gene syndromes Potocki, Lorraine Baylor College of Medicine
Augmentation of the cholinergic system in fragile X syndrome: A double-blind placebo-controlled randomized study of donepezil Reiss, Allan Stanford University
Proteomics in Drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence University of Tennessee Health Science Center
Proteomics in Drosophila to identify autism candidate substrates of UBE3A (supplement) Reiter, Lawrence University of Tennessee Health Science Center
Identification of UBE3A substrates using proteomic profiling in Drosophila Reiter, Lawrence University of Tennessee Health Science Center
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Johns Hopkins University
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Children's Hospital Boston
Connectopathic analysis of autism Sanes, Joshua Harvard University
Sex differences in early brain development: Brain development in Turner syndrome Santelli, Rebecca Knickmeyer University of North Carolina at Chapel Hill
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Massachusetts Institute of Technology
Aberrant synaptic function caused by TSC mutation in autism Sulzer, David Columbia University
TrkB agonist(s), a potential therapy for autism spectrum disorders Sun, Yi University of California, Los Angeles
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Stanford University
Gene silencing in fragile X syndrome Usdin, Karen National Institutes of Health (NIH)
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan University of California, San Diego
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Cold Spring Harbor Laboratory
White matter connections of the face processing network in children and adults Yoon, Jennifer Stanford University
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Baylor College of Medicine