|Project Title||Principal Investigator||Institution|
|Dense mapping of candidate regions linked to autistic disorder||Gregersen, Peter||Feinstein Institute for Medical Research|
|A recurrent genetic cause of autism||Gusella, James||Massachusetts General Hospital|
|Genes disrupted by balanced genomic rearrangements in autism spectrum disorders||Gusella, James||Massachusetts General Hospital|
|The role of the neurexin 1 gene in susceptibility to autism||Gusella, James||Massachusetts General Hospital/Harvard Medical School|
|Neurogenetics of candidate systems in autism (supplement)||Haines, Jonathan||Duke University|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Simons Simplex Collection Site||Klin, Ami||Yale University|
|Simons Simplex Collection Site||Kochel, Robin||Baylor College of Medicine|
|Genomic imbalances in autism||Kumar, Ravinesh||University of Chicago|
|RNA expression patterns in autism||Kunkel, Louis||Children's Hospital Boston|
|Uncovering genetic mechanisms of ASD||Kunkel, Louis||Children's Hospital Boston|
|Center for Genomic and Phenomic Studies in Autism||Lajonchere, Clara||University of Southern California|
|Epigenetic etiologies of autism spectrum disorders||LaSalle, Janine||University of California, Davis|
|Simons Simplex Collection Site||Ledbetter, David||Emory University|
|Autism and SNPs in the IGF pathway||Levine, Arnold||Princeton University|
|Simons Simplex Collection Site||Lord, Catherine||University of Michigan|
|Relevance of NPAS1/3 balance to autism and schizophrenia||McKnight, Steven||University of Texas Southwestern Medical Center|
|Simons Simplex Collection Site||Miles, Judith||University of Missouri|
|Identification and functional assessment of autism susceptibility genes||Millonig, James||University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School|
|Identifying and understanding the action of autism susceptibility genes||Monaco, Anthony||University of Oxford|
|Genetic investigation of cognitive development in autistic spectrum disorders||Morrow, Eric||Brown University|
|Pilot project to assess web-based family recruitment for autism genetics studies||Nelson, Stan; Constantino, John; Law, Paul||University of California, Los Angeles; Washington University in St. Louis; Kennedy Krieger Institute|
|Illumina, Inc.||No PI listed||Illumina, Inc.|
|Clinical and Bioinformatics Core (supplement)||Pericak-Vance, Margaret||Duke University|
|Molecular and genetic epidemiology of autism||Pericak-Vance, Margaret||University of Miami Miller School of Medicine|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.