Strategic Plan Objective Detail
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Question 3: Long-term Objective B  

$49,905,587.13
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2009 Question 3: Long-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Dense mapping of candidate regions linked to autistic disorder Gregersen, Peter Feinstein Institute for Medical Research
The role of the neurexin 1 gene in susceptibility to autism Gusella, James Massachusetts General Hospital/Harvard Medical School
Genes disrupted by balanced genomic rearrangements in autism spectrum disorders Gusella, James Massachusetts General Hospital
A recurrent genetic cause of autism Gusella, James Massachusetts General Hospital
Neurogenetics of candidate systems in autism (supplement) Haines, Jonathan Duke University
Genetic dissection of restricted repetitive behavior (RRB) Kim, Soo-Jeong University of Florida
Simons Simplex Collection Site Klin, Ami Yale University
Simons Simplex Collection Site Kochel, Robin Baylor College of Medicine
Genomic imbalances in autism Kumar, Ravinesh University of Chicago
Uncovering genetic mechanisms of ASD Kunkel, Louis Children's Hospital Boston
RNA expression patterns in autism Kunkel, Louis Children's Hospital Boston
Center for Genomic and Phenomic Studies in Autism Lajonchere, Clara University of Southern California
Epigenetic etiologies of autism spectrum disorders LaSalle, Janine University of California, Davis
Simons Simplex Collection Site Ledbetter, David Emory University
Autism and SNPs in the IGF pathway Levine, Arnold Princeton University
Simons Simplex Collection Site Lord, Catherine University of Michigan
Relevance of NPAS1/3 balance to autism and schizophrenia McKnight, Steven University of Texas Southwestern Medical Center
Simons Simplex Collection Site Miles, Judith University of Missouri
Identification and functional assessment of autism susceptibility genes Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
Identifying and understanding the action of autism susceptibility genes Monaco, Anthony University of Oxford
Genetic investigation of cognitive development in autistic spectrum disorders Morrow, Eric Brown University
Pilot project to assess web-based family recruitment for autism genetics studies Nelson, Stan; Constantino, John; Law, Paul University of California, Los Angeles; Washington University in St. Louis; Kennedy Krieger Institute
Illumina, Inc. No PI listed Illumina, Inc.
Genetic studies in autism on chromosome 7 (supplement) Pericak-Vance, Margaret Duke University
Molecular Analysis Core (supplement) Pericak-Vance, Margaret Duke University

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
3.8
$37,043,410
83 projects

3.L.B
$49,905,587
79 projects

3.L.B
$34,432,884
60 projects

3.L.B
$25,383,346
59 projects

3.L.B
$23,041,231
74 projects

$169,806,458
3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.