|Project Title||Principal Investigator||Institution|
|Neurogenomics in a model for procedural learning||Hilliard, Austin||University of California, Los Angeles|
|Neuroligin and autism||Taylor, Palmer||University of California, San Diego|
|Neuronal populations related to deficits in social emotions and cognition in autism: A neurobiological and genomics approach||Allman, John||California Institute of Technology|
|Patient-oriented research in recessive pediatric brain diseases||Gleeson, Joseph||University of California, San Diego|
|Potential role of noncoding RNAs in autism||Talebizadeh, Zohreh||Children's Mercy Hospitals and Clinics|
|Proteomics in Drosophila to identify autism candidate substrates of UBE3A||Reiter, Lawrence||University of Tennessee Health Science Center|
|Recessive genes for autism and mental retardation||Walsh, Christopher||Beth Israel Deaconess Medical Center|
|Role of micro-RNAs in ASD affected circuit formation and function||Ullian, Erik||University of California, San Francisco|
|Simons Simplex Collection Site - 1||Beaudet, Arthur||Baylor College of Medicine|
|Simons Simplex Collection Site - 10||Miles, Judith||University of Missouri|
|Simons Simplex Collection Site - 11||Peterson, Bradley||Columbia University|
|Simons Simplex Collection Site - 12||Sutcliffe, James||Vanderbilt University|
|Simons Simplex Collection Site - 13||Walsh, Christopher||Boston Children's Hospital|
|Simons Simplex Collection Site - 14||Deutsch, Curtis||University of Massachusetts Medical School|
|Simons Simplex Collection Site - 2||Bernier, Raphael||University of Washington|
|Simons Simplex Collection Site - 3||Constantino, John||Washington University in St. Louis|
|Simons Simplex Collection Site - 4||Cook, Edwin||University of Illinois at Chicago|
|Simons Simplex Collection Site - 5||Fombonne, Eric||The Research Institute of the McGill University Health Centre|
|Simons Simplex Collection Site - 6||Geschwind, Daniel||University of California, Los Angeles|
|Simons Simplex Collection Site - 7||Klin, Ami||Yale University|
|Simons Simplex Collection Site - 8||Ledbetter, David||Emory University|
|Simons Simplex Collection Site - 9||Lord, Catherine||University of Michigan|
|Studies of postmortem brain searching for epigenetic defects causing autism||Beaudet, Arthur||Baylor College of Medicine|
|The impact of autism specific genomic variations on microRNA gene expression profile||Scherer, Stephen||The Hospital for Sick Children|
|The role of Contactin-associated Protein-like 2 (CNTNAP2) and other novel genes in autism||Chakravarti, Aravinda||Johns Hopkins University School of Medicine|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.