Strategic Plan Objective Detail
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Question 3: Long-term Objective B  

Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2009 Question 3: Long-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Simons Simplex Collection Site Fombonne, Eric The Research Institute of the McGill University Health Centre
Epigenetic etiologies of autism spectrum disorders LaSalle, Janine University of California, Davis
Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy Yang, Xiangdong University of California, Los Angeles
Simons Simplex Collection Site Geschwind, Daniel University of California, Los Angeles
ACE Network: A comprehensive approach to identification of autism susceptibility genes Geschwind, Daniel University of California, Los Angeles
Pilot project to assess web-based family recruitment for autism genetics studies Nelson, Stan; Constantino, John; Law, Paul University of California, Los Angeles; Washington University in St. Louis; Kennedy Krieger Institute
Role of micro-RNAs in ASD affected circuit formation and function Ullian, Erik University of California, San Francisco
Genomic imbalances in autism Kumar, Ravinesh University of Chicago
Genetic dissection of restricted repetitive behavior (RRB) Kim, Soo-Jeong University of Florida
Simons Simplex Collection Site Cook, Edwin University of Illinois at Chicago
Simons Simplex Collection Site Deutsch, Curtis University of Massachusetts Medical School
Identification and functional assessment of autism susceptibility genes Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
Molecular and genetic epidemiology of autism Pericak-Vance, Margaret University of Miami Miller School of Medicine
Simons Simplex Collection Site Lord, Catherine University of Michigan
Simons Simplex Collection Site Miles, Judith University of Missouri
A molecular genetic study of autism and related phenotypes in extended pedigrees Piven, Joseph University of North Carolina at Chapel Hill
Identifying and understanding the action of autism susceptibility genes Monaco, Anthony University of Oxford
Pathway-based genetic studies of autism spectrum disorder Bucan, Maja University of Pennsylvania
Center for Genomic and Phenomic Studies in Autism Lajonchere, Clara University of Southern California
Relevance of NPAS1/3 balance to autism and schizophrenia McKnight, Steven University of Texas Southwestern Medical Center
Genetics of autism intermediate phenotypes Coon, Hilary University of Utah
Simons Simplex Collection Site Bernier, Raphael University of Washington
Genomic hotspots of autism Eichler, Evan University of Washington
ACE Center: Genetic contributions to endophenotypes of autism Wijsman, Ellen University of Washington
Simons Simplex Collection Site Sutcliffe, James Vanderbilt University

Objective Multiyear Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
83 projects

79 projects

60 projects

59 projects

74 projects

3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.