|Project Title||Principal Investigator||Institution|
|Identifying and understanding the action of autism susceptibility genes||Monaco, Anthony||University of Oxford|
|Pathway-based genetic studies of autism spectrum disorder||Bucan, Maja||University of Pennsylvania|
|Relevance of NPAS1/3 balance to autism and schizophrenia||McKnight, Steven||University of Texas Southwestern Medical Center|
|Genomic hotspots of autism||Eichler, Evan||University of Washington|
|Simons Simplex Collection Site||Bernier, Raphael||University of Washington|
|Unraveling the genetic etiology of autism||Sutcliffe, James||Vanderbilt University|
|Simons Simplex Collection Site||Sutcliffe, James||Vanderbilt University|
|ACE Center: Rare variant genetics, contactin-related proteins and autism||State, Matthew||Yale University|
|A genome-wide search for autism genes in the Simons Simplex Collection||State, Matthew||Yale University|
|Simons Simplex Collection Site||Pelphrey, Kevin||Yale University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.