Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

$20,162,709.18
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2009 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Role of Wnt signaling in forebrain development, synaptic physiology, and mouse behavior Reichardt, Louis University of California, San Francisco
The genetics of restricted, repetitive behavior: An inbred mouse model Lewis, Mark University of Florida
The genetic control of social behavior in the mouse Blanchard, Robert University of Hawai'i at Manoa
A comparative developmental connectivity study of face processing Joseph, Jane University of Kentucky
A mouse knock-in model for ENGRAILED 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
Serotonin, corpus callosum, and autism Lin, Rick University of Mississippi Medical Center
Characterization of a novel mouse model of restricted repetitive behaviors Moy, Sheryl University of North Carolina at Chapel Hill
Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders Malanga, C.J. University of North Carolina School of Medicine
Functional genomic dissection of language-related disorders Fisher, Simon University of Oxford
Neurobiology of sociability in a mouse model system relevant to autism Brodkin, Edward University of Pennsylvania
Neurobiology of sociability in a mouse model system relevant to autism (supplement) Brodkin, Edward University of Pennsylvania
Behavioral and physiological consequences of disrupted Met signaling Levitt, Pat University of Southern California
Dysregulation of PI3K/AKT in social interaction deficits and autism spectrum disorders with macrocephaly Parada, Luis University of Texas Southwestern Medical Center
Novel genetic animal models of autism Powell, Craig University of Texas Southwestern Medical Center
Animal models of autism: Pathogenesis and treatment Powell, Craig University of Texas Southwestern Medical Center
Transgenic mouse model to address heterogeneity in autism spectrum disorders Blakely, Randy Vanderbilt University
Mouse genetic model of a dysregulated serotonin transporter variant associated with autism Veenstra-Vanderweele, Jeremy Vanderbilt University
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Whitehead Institute for Biomedical Research
Caspr2 dysfunction in autism spectrum disorders Robbins, Elissa Yale University
Integrated approach to the neurobiology of autism spectrum disorders Vaccarino, Flora Yale University