Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2010 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Serotonin, corpus callosum, and autism Lin, Rick University of Mississippi Medical Center
Shank3 mutant characterization in vivo Kouser, Mehreen University of Texas Southwestern Medical Center
Small-molecule compounds for treating autism spectrum disorders Philpot, Ben The University of North Carolina at Chapel Hill
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Massachusetts Institute of Technology
Synaptic deficits of iPS cell-derived neurons from patients with autism Mao, Rong Stanford University
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie New York University
Systematic analysis of neural circuitry in mouse models of autism Osten, Pavel Cold Spring Harbor Laboratory
The genetic control of social behavior in the mouse Blanchard, Robert University of Hawai'i at Manoa
The genetics of restricted, repetitive behavior: An inbred mouse model Lewis, Mark University of Florida
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
The role of SHANK3 in the etiology of autism spectrum disorder Bangash, M. Ali Johns Hopkins University
Transgenic mouse model to address heterogeneity in autism spectrum disorders Blakely, Randy Vanderbilt University
Using Drosophila to model the synaptic function of the autism-linked NHE9 Littleton, J. Troy Massachusetts Institute of Technology
Using induced pluripotent stem cells to identify cellular phenotypes of autism Dolmetsch, Ricardo Stanford University
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Stanford University
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Whitehead Institute for Biomedical Research
Vasopressin receptors and social attachment Young, Larry Emory University