Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2010 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Genomic resources for identifying genes regulating social behavior Young, Larry Emory University
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Duke University
Functional study of synaptic scaffold protein SHANK3 and autism mouse model Jiang, Yong-Hui Duke University
Neurogenetic model of social behavior heterogeneity in autism spectrum disorders Platt, Michael Duke University
Investigating the effects of chromosome 22q11.2 deletions Karayiorgou, Maria Columbia University
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Columbia University
Analysis of cortical circuits related to ASD gene candidates Zador, Anthony Cold Spring Harbor Laboratory
16p11.2: defining the gene(s) responsible Mills, Alea Cold Spring Harbor Laboratory
Novel models to define the genetic basis of autism Mills, Alea Cold Spring Harbor Laboratory
Systematic analysis of neural circuitry in mouse models of autism Osten, Pavel Cold Spring Harbor Laboratory
Novel probiotic therapies for autism Patterson, Paul California Institute of Technology
Interaction between MEF2 and MECP2 in the pathogenesis of autism spectrum disorders - 1 Lipton, Stuart Burnham Institute
Interaction between MEF2 and MECP2 in the pathogenesis of autism spectrum disorders -2 Nakanishi, Nobuki Burnham Institute
Neurobiological mechanism of 15q11-13 duplication autism spectrum disorder Anderson, Matthew Beth Israel Deaconess Medical Center
Characterization of autism susceptibility genes on chromosome 15q11-13 Smith, Stephen Beth Israel Deaconess Medical Center
Identifying genetic modifiers of rett syndrome in the mouse Buchovecky, Christine Baylor College of Medicine
Modeling and pharmacologic treatment of autism spectrum disorders in Drosophila McDonald, Thomas Albert Einstein College of Medicine of Yeshiva University