Strategic Plan Objective Detail
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Question 4: Objective 5  

Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2008 Question 4: Objective 5 projects (EXCEL)
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Project Title Principal Investigator Institution
Steroid receptors and brain sex differences Auger, Anthony University of Wisconsin - Madison
Regulation of MET expression in autism disorder and forebrain ontogeny Bergman, Mica Vanderbilt University
Distinct function of the neuroligin 3 postsynaptic adhesion complex Budreck, Elaine Columbia University
The role of Shank3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
Molecular determinants of L-type calcium channel gating Colecraft, Henry Columbia University
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health
Investigation of the role of MET kinase in autism Dawson, Ted Johns Hopkins University School of Medicine
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Duke University
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Duke University Medical Center
Generation of genetic models of autism in mice Fishell, Gordon New York University School of Medicine
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Columbia University
A better understanding of the therapeutic actions of specific neuroleptics in autism Greengard, Paul The Rockefeller University
Exploring the role of synaptic proteins in mouse models of autism Heintz, Nathaniel The Rockefeller University
Analysis of FGF17 roles and regulation in mammalian forebrain development Hoch, Renee University of California, San Francisco
Analysis of 15q11-13 GABA-A receptor defects in autism Hogart, Amber University of California, Davis
Cellular and molecular alterations in gabaergic inhibitory circuits by mutations in MECP2, a gene implicated in the Rett syndrome of the autism spectrum disorders Huang, Z. Josh Cold Spring Harbor Laboratory
Neocortical regionalization: Analysis of genetic and epigenetic influences Huffman, Kelly University of California, Riverside
Neurexin-neuroligin trans-syanptic interaction in learning and memory Kandel, Eric Columbia University
Testing the effects of cortical disconnection in non-human primates Krauzlis, Richard Salk Institute for Biological Studies
Neurodevelopmental mechanisms of social behavior Levitt, Pat Vanderbilt University
The functional neuroanatomy of memory systems in the human brain Martin, Alex National Institutes of Health
A mouse knock-in model for Engrailed 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
Novel models to define the genetic basis of autism Mills, Alea Cold Spring Harbor Laboratory
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University
Dysregulation of p13/AKT in mouse models for social interaction deficits and for ASD with macrocephaly Parada, Luis University of Texas Southwestern Medical Center