Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Interdisciplinary investigation of biological signatures of autism subtypes  

A major roadblock to preventing and more adequately treating autism is that there are many causes and many types. It is currently impossible to determine what type of autism a child has at diagnosis. In order to solve this problem, this study will examine the biology of a large number of children with autism to identify biological signatures of different types of autism. As an extension of the Autism Phenome Project at the M.I.N.D. Institute, preschoolers with ASD and with typical development (TD) will receive full medical evaluation, medical record review, environmental exposure assessment, blood based genetic and immune profiling, structural magnetic resonance imaging (MRI), EEG based studies of auditory processing, and comprehensive developmental and neuropsychological evaluations. This research will lead to identification of several subtypes of autism, which will enable more effective efforts at preventing future cases of autism and treating children with an existing autism diagnosis. Project Status


Funder National Institutes of Health
Fiscal Year Funding $1,429,402.00
Project Number 1R01MH089626-01
Principal Investigator Amaral, David
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2LA. Complete a large-scale, multi-disciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people by 2020. IACC Recommended Budget: $126,200,000 over 12 years.
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 Interdisciplinary investigation of biological signatures of autism subtypes (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Interdisciplinary investigation of biological signatures of autism subtypes | $1,398,688.00 | 2010 | 5R01MH089626-02