Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Anatomy of primate amygdaloid complex  

The amygdala is a complex brain region, and the overarching goal of this project is to define the organization and connections of cell bodies in the macaque monkey amygdaloid complex. The amygdala is associated with a variety of psychiatric disorders including anxiety, depression, autism, and schizophrenia, many of which are first manifested during the peripubertal period. Previous studies showed that the amygdala in typically developing boys undergoes a 40% increase in volume between 7 and 18 years of age. This expansion occurs at a time when the cerebral volume decreases by about 10%. In boys with autism, the amygdala reaches its adult size by 7 years and does not increase thereafter. This study in macaque monkeys will determine the morphological features of the amygdala's postnatal development. Primates will be used because it is not feasible to carry out this type of analysis in postmortem human brain tissue. Project Status


Funder National Institutes of Health
Fiscal Year Funding $106,669.00
Project Number 5P51RR000169-48
Principal Investigator Amaral, David
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of California, Davis
State/Country California
Web Link 1 Anatomy of primate amygdaloid complex (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Anatomy of primate amygdaloid complex | $114,105.00 | 2010 | 2P51RR000169-49
Anatomy of primate amygdaloid complex | $81,333.00 | 2008 | P51RR000169-47