Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Brain glutamate concentrations in autistic adolescents by MRS  

Previous studies have suggested that the glutamate system may be abnormal in the brain of adolescents with autism and that these abnormalities may arise after early childhood. A non-invasive way of measuring glutamate in the brain is by using magnetic resonance spectroscopy (MRS). This technique is based on the same principles as magnetic resonance imaging (MRI), but, instead of images, it provides high frequency spectra that allow the investigators to study the biochemical composition of the brain. In this research, the glutamate concentrations in the brains of adolescents (12-17 years) will be compared between children that are typically developing and those that have autism. The goal of the study is to determine whether adolescents with autism exhibit increased glutamate concentrations. Project Status


Funder National Institutes of Health
Fiscal Year Funding $1,224.00
Project Number 5M01RR000071-46
Principal Investigator Anagnostou, Athanasius
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SE. Support at least two studies to determine if there are subpopulations that are more susceptible to environmental exposures (e.g., immune challenges related to infections, vaccinations, or underlying autoimmune problems) by 2012. IACC Recommended Budget: $8,000,000 over 2 years.
Federal or Private? Federal
Institution Mount Sinai School of Medicine
State/Country New York
Web Link 1 Brain glutamate concentrations in autistic adolescents by MRS (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Brain glutamate concentrations in autistic adolescents by MRS | $9,703.00 | 2008 | M01RR000071-45