Project Detail
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Steroid receptors and brain sex differences  

This study investigates the functional role of ligand-independent activation of estrogen receptors (ER) in the developing brain. Recent data indicate that acute changes in dopamine transmission during the first few days of life can dramatically alter the developmental organization of social play behavior by activating ER in a ligand-independent manner. As social play behavior is dramatically disrupted in children with autism and Asperger's syndrome, and social play behavior in rodents has been used as a rodent model for the study of autism, it is possible that these data will further understanding of how sexually dimorphic social disorders occur during brain development. Project Status


Funder National Institutes of Health
Fiscal Year Funding $301,301.00
Project Number 5R01MH072956-04
Principal Investigator Auger, Anthony
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SB. Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5 years.
Federal or Private? Federal
Institution University of Wisconsin - Madison
State/Country Wisconsin
Web Link 1 Steroid receptors and brain sex differences (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Steroid receptors and brain sex differences | $301,240.00 | 2010 | 5R01MH072956-05
Steroid receptors and brain sex differences | $301,359.00 | 2008 | R01MH072956-03