Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Regulation of MET expression in autism disorder and forebrain ontogeny  

The purpose of this National Research Service Award is to provide support to an individual for combined M.D./Ph.D. and other dual doctoral degree training. Researchers recently found that a single nucleotide polymorphism (SNP) in a region that regulates the transcription of the human MET gene (rs1858830 allele 'C') is strongly associated with ASD. This mutation reduces gene transcription, which effectively reduces the amount of the gene available to be turned into functional protein. The goals of this study include: 1) determining the transcriptional regulators of a functional variant in the human MET promoter that is associated with ASD vulnerability and 2) defining the mechanisms through which the mouse Met receptor tyrosine kinase influences forebrain development. Results from these studies will help to explain how dysregulation of MET may lead to altered brain development and increased ASD susceptibility. Project Status


Funder National Institutes of Health
Fiscal Year Funding $25,800.00
Project Number 5F30MH083474-03
Principal Investigator Bergman, Mica
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.
Federal or Private? Federal
Institution Vanderbilt University
State/Country Tennessee
Web Link 1 Regulation of MET expression in autism disorder and forebrain ontogeny (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Regulation of MET expression in autism disorder and forebrain ontogeny | $25,583.00 | 2008 | F30MH083474-02