Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The genetic control of social behavior in the mouse  

Autism spectrum disorders (ASDs) are defined solely in terms of behavior, and their diagnostic symptoms have presented a challenge in developing mouse models that facilitate research on the biology of these disorders. In this study, repetitive behaviors will be analyzed in mice with mutations in a number of candidate genes for ASD. These genes include Engrailed 2, Reelin, fragile X mental retardation 1 (FMR1), methyl-CpG-binding protein 2 (MeCP2), oxytocin, and arginine vasopressin 1b receptor, which have all previously shown associations with deficient social behaviors or enhanced representation in ASD or related conditions. This research will integrate a detailed evaluation of behaviors potentially related to ASD with analysis of the effects of mutations in genes that may be related to these disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $346,000.00
Project Number 1R01MH081845-01A2
Principal Investigator Blanchard, Robert
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution University of Hawai'i at Manoa
State/Country Hawaii
Web Link 1 The genetic control of social behavior in the mouse (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects The genetic control of social behavior in the mouse | $346,000.00 | 2010 | 5R01MH081845-02