This is an individual National Research Service Award for pre-doctoral research training, which provides support for promising doctoral candidates who will be performing dissertation research and training in a scientific health-related field. A study examining the gene expression changes across two groups of autistic patients with known genetic causes versus healthy controls revealed Janus kinase and microtubule-interacting protein 1, JAKMIP1, as a gene that might be implicated in autism. JAKMIP1 is predominantly found in neurons and regulates the expression and possible transport of GABA receptors and GABAergic systems that are known to be abnormal in autism spectrum disorder ASD. This research will use a mouse model to follow how the expression of this protein changes during development to adulthood. The impact of removing the Jakmip1 protein will also be assessed. This study will shed light on the mechanism by which aberrant JAKMIP1 levels could result in autism and may further implicate JAKMIP1 as an autism-susceptibility gene. These discoveries will aid in pre-symptomatic diagnosis and early behavioral intervention for autistic children as well as the design of pharmaceuticals.