Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Genetic and epigenetic interactions in a mouse model for autism  

In this study, Dr. Carpenter and colleagues will examine the interaction between a specific gene and an environmental factor in the development of autistic-like behaviors in a mouse model. The reelin gene is a candidate genetic factor for autism and is important for the development of the cerebral cortex and cerebellum. Mice with reduced levels of expression of this gene have neurodevelopmental defects which result in behavioral abnormalities. This research will examine the effects of an environmental factor hypothesized to be a risk factor for autism (organophosphate exposure during the prenatal period) on the development of autistic behaviors in mice which express low levels of the protein encoded by the reelin gene. It will also determine whether reduced reelin expression in combination with organophosphate exposure leads to changes in the anatomy of brain regions associated with these behaviors. Project Status


Funder Autism Speaks
Fiscal Year Funding $60,000.00
Project Number 2552
Principal Investigator Carpenter, Ellen
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.
Federal or Private? Private
Institution David Geffen School of Medicine at University of California, Los Angeles
State/Country California
Web Link 1 Genetic and epigenetic interactions in a mouse model for autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Genetic and epigenetic interactions in a mouse model for autism | $60,000.00 | 2008 | 2552