Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Behavioral and genetic biomarker development for autism and related disorders  

While it is clear that autism has a strong inherited genetic component, many large scale genetic studies that have relied only on a general ASD diagnosis or information collected only on affected individuals have had limited success in identifying risk alleles. An alternative is to examine behavioral biomarkers, especially for language ability, to assist with gene mapping, and to extend the data collection beyond just the individual diagnosed with autism to include family members that also exhibit a language delay. This project will use this approach by utilizing an existing database that contains clinical and genetic information for people with autism and all their family members in order to identify biomarkers for risk of autism. Potential behavioral biomarkers will be validated and candidate genes will be examined for DNA variations in sequence or copy number. Overall, the combined analysis of behavioral and genetic biomarkers will enable development of more accurate models for the prediction of risk for autism spectrum disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $499,543.00
Project Number 1RC1MH088288-01
Principal Investigator Brzustowicz, Linda
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Federal
Institution Rutgers, The State University of New Jersey - New Brunswick
State/Country New Jersey
Web Link 1 Behavioral and genetic biomarker development for autism and related disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Behavioral and genetic biomarker development for autism and related disorders | $494,132.00 | 2010 | 5RC1MH088288-02