Project Detail
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Office of Autism Research Coordination (OARC) logo

Distinct function of the neuroligin 3 postsynaptic adhesion complex  

The purpose of this National Research Service Award is to provide support to an individual for combined M.D./Ph.D. and other dual doctoral degree training. The goal of this research is to elucidate the role of neuroligins (NLs) in the formation of synapses, a process which is critical for the precise wiring of the nervous system and could be dysfunctional in ASD. One particular NL isoform, neuroligin 3, has been implicated in autism spectrum disorders. In this study, experiments will use a combination of cellular assays in dissociated hippocampal neurons, molecular biology approaches, and biochemical methods to probe protein-protein interactions between neuroligins and other synaptic proteins like neurexins and neurotransmitter receptors. The results obtained in the proposed experiments will yield a detailed functional characterization of NLs that will provide the basis for understanding cellular defects associated with autism spectrum disorders. Project Status


Funder National Institutes of Health
Fiscal Year Funding $37,784.00
Project Number 5F30MH083473-03
Principal Investigator Budreck, Elaine
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Columbia University
State/Country New York
Web Link 1 Distinct function of the neuroligin 3 postsynaptic adhesion complex (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Distinct function of the neuroligin 3 postsynaptic adhesion complex | $45,972.00 | 2008 | F30MH083473-02