Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Maternal inflammation alters fetal brain development via tumor necrosis factor-alpha  

This is an individual National Research Service Award for post-doctoral research training, which provides support to promising fellowship applicants with the potential to become productive, independent investigators in scientific health-related research fields. In this proposed study, the fellow will examine the influence of maternal illness on the health of offspring. Maternal illness has been associated with a number of problems in brain development in the child, including autism and schizophrenia. The fellow will study a mouse model in which illness and inflammation in the pregnant mother has significant effects on the number and timing of neurons being born in the fetal brain. The goal of this study is to examine the mechanisms by which fetal brain development is altered in this model, focusing on the role of a single inflammatory molecule (TNF-alpha), which could be clinically targeted to prevent developmental diseases. Project Status


Funder National Institutes of Health
Fiscal Year Funding $12,928.00
Project Number 5F32NS060427-02
Principal Investigator Carpentier, Pamela
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Funding Budget: $9,800,000 over 4 years.
Federal or Private? Federal
Institution Stanford University
State/Country California
Web Link 1 Maternal inflammation alters fetal brain development via tumor necrosis factor-alpha (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Maternal inflammation alters fetal brain development via Tumor Necrosis Factor-alpha | $49,646.00 | 2008 | F32NS060427-01A1