Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Neural mechanisms underlying obsessive compulsiveness in ASD  

This is an individual National Research Service Award for pre-doctoral research training, which provides support for promising doctoral candidates who will be performing dissertation research and training in a scientific health-related field. From a public health perspective, it is imperative to learn more about the neural systems underlying obsessiveness and compulsiveness in autism spectrum disorders (ASD), given the high prevalence of these symptoms in ASD patients. Recent studies have identified functional abnormalities of the default network (i.e., a set of brain regions activated during passive task states and whose activity and function may play an important role in the development of several neuropsychiatric disorders). In addition, recent studies of ASD have shown that the disorder may be largely characterized by deficits in cognitive processes under the control of default mode structures (i.e., known to modulate social, emotional, self-relevant tasks) that might be due to dysfunction of the default network. The study proposed here aims to better understand this brain-behavior relationship. This knowledge may suggest new therapeutic routes and diagnostic techniques to help treat obsessive and compulsive symptoms in ASD. Project Status


Funder National Institutes of Health
Fiscal Year Funding $32,236.00
Project Number 1F31MH086273-01
Principal Investigator Carrasco, Melisa
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.
Federal or Private? Federal
Institution University of Michigan
State/Country Michigan
Web Link 1 Neural mechanisms underlying obsessive compulsiveness in ASD (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Neural mechanisms underlying obsessive compulsiveness in ASD | $32,934.00 | 2010 | 5F31MH086273-02