Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Gross morphological correlates to the minicolumnopathy of autism  

The minicolumn is a basic anatomical and physiological element of the mammalian cerebral cortex in the brain, comprising a linear array of pyramidal cell bodies (neurons), their projections that conduct electrochemical information between cells, and accompanying GABAergic interneurons. Postmortem studies of the organization of pyramidal cell arrays in autism have revealed that minicolumns in the brains of autistic patients are narrower. This study will use 58 cases from the Autism Tissue Program (ATP) that have clinical documentation and postmortem magnetic resonance imaging (MRI) data in an attempt to establish a correlation between autopsy and neuroimaging findings in autism. The intent is to develop markers of the condition that can be detected while the patient is alive. Another innovative aspect of the proposal is an attempt to validate current diagnostic screening techniques against autopsy findings by correlating clinical parameters with neuropathological/neuroimaging data. Project Status


Funder National Institutes of Health
Fiscal Year Funding $287,554.00
Project Number 1R01HD065279-01
Principal Investigator Casanova, Manuel
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Louisville
State/Country Kentucky
Web Link 1 Gross morphological correlates to the minicolumnopathy of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Gross morphological correlates to the minicolumnopathy of autism | $259,000.00 | 2010 | 5R01HD065279-02