Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Building a selective inhibitory control tone in autism: An rTMS study  

Some reports have shown that autism is associated with structural abnormalities in the brain. A GABAergic interneuron called a double-bouquet cell usually protects the areas around minicolumns, which help give the cortical area of the brain structure. Having too many axon terminals, dendrites, and other cell matter too close to the minicolums has been associated with autism. This study will try to strengthen double-bouquet cells to increase their power to inhibit encroachment on the space around the minicolumns. This will be done in autistic patients and controls by inducing electrical current into the double-bouquet cells (by creating a magnetic field) through Transcranial Magnetic Stimulation (TMS). Outcome measures will include behavioral and electrophysiological measures. The results of the proposed study will help understand the specific social communication and cognitive deficits associated with developmental abnormalities of functions within cortical circuitry, and thereby contribute to understanding the brain substrates of behavioral dysfunctions typical for autism. The research represents a new development in combining TMS with functional outcome measures (cognitive event-related potential (ERP), EEG), using TMS as a theory-guided psychiatric therapy in autism. Project Status


Funder National Institutes of Health
Fiscal Year Funding $222,000.00
Project Number 1R01MH086784-01
Principal Investigator Casanova, Manuel
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective 4O. Not specific to Question 4 objectives
Federal or Private? Federal
Institution University of Louisville
State/Country Kentucky
Web Link 1 Building a selective inhibitory control tone in autism: An rTMS study (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Building a selective inhibitory control tone in autism: An rTMS study | $222,000.00 | 2010 | 5R01MH086784-02