Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Ethnicity and the elucidation of autism endophenotypes  

Research has focused on identifying subgroups of people with autism, or "endophenotypes," in order to accelerate the discovery of autism's genetic basis. People with the same endophenotype share certain traits, which may include morphological, physiological or behavioral features. This research project explores a candidate endophenotype based on motor ability. Dr. Constantino's fellow will evaluate the coordination of movement in school-aged children with autism and their siblings. The subjects will come from a well-characterized sample of sibling pairs that either share autism (concordant) or do not share autism (discordant), and this sample includes both Caucasian and African-American families. By analyzing how motor abilities vary among autistic and non-autistic siblings, this work will test the reliability of this candidate endophenotype. In addition, the early development of motor abilities will be studied in a different sample of high-risk infant siblings of individuals with autism. Project Status


Funder Autism Speaks
Fiscal Year Funding $61,000.00
Project Number 2306
Principal Investigator Constantino, John
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.
Federal or Private? Private
Institution Washington University in St. Louis
State/Country Missouri
Web Link 1 Ethnicity and the elucidation of autism endophenotypes (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Ethnicity and the elucidation of autism endophenotypes | $0.00 | 2010 | 2306
Ethnicity and the elucidation of autism endophenotypes | $61,000.00 | 2008 | 2306