Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Role of excitation and inhibition in Rett syndrome  

This is an individual National Research Service Award for pre-doctoral research training, which provides support for promising doctoral candidates who will be performing dissertation research and training in a scientific health-related field. Rett syndrome (RTT) is a progressive neurodevelopmental disease caused predominantly by loss-of-function mutations in the X-linked gene encoding the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2). Recent reports reveal that producing too much MeCP2 is also detrimental to neurological function. This project will examine the neurophysiological properties of neurons upon loss or doubling of MeCP2, develop and characterize conditional MeCP2 knockout mouse models specific to excitatory and inhibitory neurons, and assess their behavioral and neurophysiological phenotypes. The study will help elucidate the impact of altered MeCP2 levels on neuronal function and identify the contribution of global excitatory and inhibitory neuronal activity to Rett syndrome phenotypes. This research will give insight into RTT pathogenesis and provide new target pathways for investigating potential therapeutic interventions. Project Status


Funder National Institutes of Health
Fiscal Year Funding $32,922.00
Project Number 5F31MH078678-02
Principal Investigator Chao, Hsiao-Tuan
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution Baylor College of Medicine
State/Country Texas
Web Link 1 Role of excitation and inhibition in Rett syndrome (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects N/A