Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Molecular determinants of L-type calcium channel gating  

Calcium entry through plasma membrane L-type calcium channels regulates many essential biological functions, including muscle contraction, hormone release, and gene expression. Dysregulation of L-type channel functional expression underlies a wide range of diseases including life-threatening atrial arrhythmias, autism, night blindness, and deafness. Fundamental molecular understanding of structure-function mechanisms underlying L-type channel functional expression will be increased using electrophysiological assays, fluorescence resonance energy transfer detection of protein interactions, and immunofluorescence. The results will be used to identify (patho)physiological roles and therapeutic potential of L-type channels. Project Status


Funder National Institutes of Health
Fiscal Year Funding $402,500.00
Project Number 5R01HL069911-08
Principal Investigator Colecraft, Henry
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Columbia University
State/Country New York
Web Link 1 Molecular determinants of L-type calcium channel gating (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Molecular determinants of L-type calcium channel gating | $402,500.00 | 2008 | R01HL069911-07