Project Detail
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Prenatal exposure to polyfluoroalkyl compounds in the EMA study  

Preliminary research studies have implicated a complex interplay of immunologic and genetic susceptibility factors with environmental exposures as critical elements in the development of autism spectrum disorders (ASD). The primary goal of this study is to identify early biologic markers for ASD in a large case-control study consisting of 1,200 mother-baby pairs (400 with ASD, 400 with mental retardation (MR) but not autism, and 400 general population (GP) controls) with an added family-based component that includes 60 siblings of ASD cases and 60 siblings of MR controls. Researchers will use blood specimens taken during pregnancy to explore the interplay between markers of endocrine function and environmental exposures, including the organic compound polyfluoroalkyl compounds (PFCs), during critical periods of fetal brain development and identify factors that contribute to ASD risk. In the long-term, a better understanding of the underlying biology may suggest appropriate strategies for early intervention and contribute to the eventual prevention of this often devastating and usually life-long disability. Project Status


Funder National Institutes of Health
Fiscal Year Funding $272,062.00
Project Number 1R01ES019003-01
Principal Investigator Croen, Lisa
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.
Federal or Private? Federal
Institution Kaiser Foundation Research Institute
State/Country California
Web Link 1 Prenatal exposure to polyfluoroalkyl compounds in the EMA study (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Prenatal exposure to polyfluoroalkyl compounds in the EMA study | $130,465.00 | 2010 | 5R01ES019003-02