Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

MRI study of brain development in school age children with autism  

Dr. Hazlett's research team at University of North Carolina (UNC) has developed image processing tools specifically designed for highly-efficient, reliable, and valid processing of pediatric magnetic resonance imaging (MRI) data. Their early results from a longitudinal MRI study of brain development demonstrate generalized enlargement of white and gray matter volume in cerebral cortex in autistic individuals at age 2 yrs. This study will track brain development using MRI/DTI (diffusion tensor imaging) scans in 6-10 year olds with autism and controls who have already participated in the longitudinal MRI study of brain development. Forty-two children with autism who have been scanned at ages 2 and 4 will be rescanned at age 6-10. Controls will include typically-developing children and a small subset of children with developmental delay. This study will provide more definitive information about the trajectory of brain growth (regions, tissues, structures, and fiber tracts) as measured on MRI and DTI. Additionally, Dr. Hazlett will be able to explore behavioral features associated with social cognition and ritualistic repetitive behaviors in an in-depth manner now that the children are older (6-10 years old), which may provide important insights into the development of neurobiological mechanisms and behavioral phenotypes in autism. Project Status


Funder Autism Speaks
Fiscal Year Funding $149,864.00
Project Number 2099
Principal Investigator Hazlett, Heather Cody
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2LA. Complete a large-scale, multi-disciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people by 2020. IACC Recommended Budget: $126,200,000 over 12 years.
Federal or Private? Private
Institution University of North Carolina at Chapel Hill
State/Country North Carolina
Web Link 1 MRI study of brain development in school age children with autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects MRI study of brain development in school age children with autism | $0.00 | 2010 | 2099
MRI study of brain development in school age children with autism | $150,000.00 | 2008 | 2099