Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Integrated function/structure image analysis in autism  

Functional magnetic resonance imaging (fMRI) studies in subjects with autism spectrum disorder (ASD) indicate that there may be differences in regional brain function in response to several different face recognition and social attribute discrimination tasks. In a few specific brain regions, fMRI has shown differences between normal controls and ASD subjects. However, these previous studies have been limited in terms of their ability to localize information spatially and to delineate subgroups within ASD. This proposed research is centered on developing unique mathematical approaches that consider functional and structural information together in order to develop more sensitive and spatially-specific measurements. These approaches will be tested in their ability to separate subgroups in the autism spectrum (autism, Asperger's, PDD-NOS) using both functional and structural measures. Project Status


Funder National Institutes of Health
Fiscal Year Funding $339,441.00
Project Number 5R01NS035193-12
Principal Investigator Duncan, James
Received ARRA Funding? No
Strategic Plan Question Question 1: When Should I Be Concerned? (Diagnosis)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.
Federal or Private? Federal
Institution Yale University
State/Country Connecticut
Web Link 1 Integrated function/structure image analysis in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Integrated function/structure image analysis in autism | $339,800.00 | 2008 | R01NS035193-11