Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses  

This is an individual National Research Service Award for post-doctoral research training, which provides support for promising Fellowship Applicants with the potential to become productive, independent investigators in scientific health-related research fields. Synaptic plasticity is believed to underlie learning and memory, the basis for behavior. Neuroligins are synaptic proteins, and mutations in the genes coding for these proteins and their binding partners have been found in autism spectrum disorders. These disorders are characterized by impaired social interactions, and several mice that either lack the neuroligin 1 gene or have a specific mutation added that is found in autistic patients are known to have impaired social behavior. Recent studies have found mutations in many activity-dependent genes in autistic patients, and it is possible that the neuroligins are important in activity-dependent synaptic plasticity. The objective of this study is to investigate the role of neuroligins in synaptic plasticity at excitatory and inhibitory synapses in order to better understand the role of neuroligins in physiology and pathophysiology. Project Status


Funder National Institutes of Health
Fiscal Year Funding $57,194.00
Project Number 1F32MH086224-01
Principal Investigator Engelman, Holly
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution Albert Einstein College of Medicine of Yeshiva University
State/Country New York
Web Link 1 Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses | $59,918.00 | 2010 | 5F32MH086224-02