Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Genome-wide environment interaction study for autism: The SEED study  

Improving the understanding of gene-environment interaction (GxE) as a causative factor in autism has been identified as a research priority in the NIH Interagency Autism Coordinating Committee's (IACC's) Strategic Plan for Autism Spectrum Disorders (ASD) Research as well as in the IOM's Report on Autism and the Environment. However, empirical investigations of GxE in autism remain scarce. The Study to Explore Early Development (SEED) is a multisite ASD case-control investigation recruiting 900 3-5 year old children with ASDs, 900 typically developing controls, and 900 children with non-autism developmental impairments. This grant will support research on a subset of SEED participants, including 500 autism cases and 500 controls to identify genes whose effects on ASD may vary across environmental exposure categories related to pre-natal infection, maternal medication use, or smoking and drinking during pregnancy. This work will accelerate future efforts centered around gene-environment interaction both in the full set of SEED participants and in other data sets for autism. Project Status


Funder National Institutes of Health
Fiscal Year Funding $723,953.00
Project Number 1R01ES019001-01
Principal Investigator Fallin, Margaret Danielle
Received ARRA Funding? Yes
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3SC. Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene – environment research by 2011. IACC Recommended Budget: $27,800,000 over 5 years.
Federal or Private? Federal
Institution Johns Hopkins University
State/Country Maryland
Web Link 1 Genome-wide environment interaction study for autism: The SEED study (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Genome-wide environment interaction study for autism: The SEED study | $704,956.00 | 2010 | 5R01ES019001-02