Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Anterior cingulate and fronto-insular related brain networks in autism  

Von Economo neurons (VENs) are large, bipolar, spindle shaped neurons that are most abundant in the human cortex and may be involved in the fast and intuitive assessment of complex situations. Deficiencies of VENs may result in the inability to process complex, unpredictable, and novel information in a social context. There is evidence linking the behavioral deficits observed in patients with autism to the functions of certain brain regions, suggesting that the impairments of social and cognitive abilities may relate to abnormal development of VENs. This research will investigate abnormalities of cortical brain networks involved in sensory, perceptual, and cognitive processes in high-functioning patients with ASD. Using an innovative approach involving the integration of sensory/perceptual and cognitive tasks, multi-modal neuroimaging, and clinical testing, this research will provide specific and comprehensive functional and anatomical insight into the neural mechanisms of high-functioning autism and may also guide novel treatment approaches. Project Status


Funder National Institutes of Health
Fiscal Year Funding $194,745.00
Project Number 5R21MH083164-02
Principal Investigator Fan, Jin
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution Mount Sinai School of Medicine
State/Country New York
Web Link 1 Anterior cingulate and fronto-insular related brain networks in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
History/Related Projects Anterior cingulate and fronto-insular related brain networks in autism | $222,060.00 | 2008 | R21MH083164-01